In this Valentine’s Day edition of SetSet, April Pride explores MDMA’s unique ability to unlock empathy, boost connection, and dissolve emotional barriers. Once known as Ecstasy, MDMA has a rich history of therapeutic use before its clubland fame and eventual classification as a Schedule I substance. April reflects on her favorite entheogen, shares listener stories, trip tips, and personal insights on why MDMA may be the best place to start your psychedelic journey. This episode includes a crash course in safe dosing, duration, and what makes MDMA such a powerful ally for healing—and love.
🔵 Key Takeaways
MDMA was first synthesized in 1912 and became popular in therapy before being banned in 1985.
It’s not a psychedelic but an empathogen, promoting emotional openness and connection.
Typical doses range from 80–125 mg, but always test and start with half.
Effects include heightened mood, empathy, and warmth—but can also affect body temperature.
MDMA is resurging in therapeutic contexts, especially for PTSD and trauma work.
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🔵 Timestamps
[00:00] Introduction: What is an empathogen?
[00:57] MDMA’s origins and transition from therapy to the rave scene
[01:55] Listener story: Why you should open your heart before your mind
[03:03] Sequencing psychedelics and the emotional foundation MDMA offers
[03:52] Trip tips: effects, temperature sensitivity, and how to dose safely
[04:51] Dissolving crystals in tequila (yes, really) and what to avoid
[05:46] Snorting, water-solubility, and Neti Pot hacks
[06:00] Must-read: 1980s Dallas ecstasy culture via Playboy and MAPS
[06:45] What to watch and listen to for MDMA context
[07:11] Song of the week: The Streets – “Blinded by the Lights”
[08:17] Community call: share your MDMA story via SpeakPipe or Instagram
🔵 Guest Spotlight
Community perspectives shared anonymously. Expert insight from April Pride.
🔵 Additional Resources
Read and listen about MDMA on SetSet here
MAPS.org – MDMA-assisted therapy research
Documentary: Limelight on Amazon Prime
Have you experienced a therapeutic or transformative moment with MDMA? How has it shifted your relationships or self-perception?👇 Let’s talk about it in the comments.
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