Cannabis microdosing is having a moment—and for good reason. In this episode, April Pride explores how low doses of THC (often with CBD) can help women manage stress, pain, and mood—without getting high. Featuring real-life wisdom from former mayor and senior cannabis advocate Sherry Horn and cannabis entrepreneur Hope Wiseman, this episode offers a practical guide to understanding product labels, experimenting with ratios, and shopping smart. Plus, we break down psilocybin microdosing options and introduce a new 10-week microdose protocol launching in Seattle. Want to float through your day—not fly? This episode is for you.
🔵 Key Takeaways
Cannabis microdosing means flying low—not high—while still getting therapeutic benefits.
Start “low and slow,” especially with tinctures or gummies: 1 drop or 2 mg is a smart start.
Understand ratios: 1:1 CBD:THC feels like champagne; 20:1 is like a light beer.
Budtenders can’t offer medical advice—but they are label pros. Know what you want before you shop.
Microdosing psilocybin (0.15g) can help with seasonal depression, migraines, and creativity.
🔵 Timestamps
[00:00] April introduces cannabis microdosing and intention
[01:09] Sherry Horn on guiding seniors through their first cannabis experiences
[01:50] Welcome to “How to Do the Pot” audio newsletter
[03:00] How cannabis microdosing works (CBD:THC ratios explained)
[04:13] Hope Wiseman’s tips for a better dispensary experience
[05:23] Psilocybin microdose options from Of Like Minds
[07:00] Intro to a 10-week guided microdosing protocol in Seattle
[08:00] High Five: How to read cannabis labels and THC percentages
[10:30] Strain guide: Canatonic, Harlequin, and the 20:1 strain
[12:00] Comparing psilocybin and cannabis microdosing outcomes
🔵 Featured Guests
Sherry Horn
Hope Wiseman
🔵 Additional Resources
SetSet Blog: “Cannabis Strain Families”
SetSet Blog: “The Science and Safety of Microdosing Mushrooms for Women”
🎙️ SetSet Podcast: Ep. 82 “CBD for Sleep Support: What Works”
🎙️ SetSet Podcast: Ep. 81 “CBD for Inflammation: Relief for Women”
🎙️ SetSet Podcast: Ep. 17 “Psilocybin Microdosing Dosage Tips”
Substack: “My Midlife Microdosing Journey is About to Begin”
Substack: “Why Midlife Women are Microdosing, Self-Treating, and Reclaiming Their Health”
What’s your ideal microdose—psilocybin or cannabis? What outcomes are you chasing, and how do you find your sweet spot? 👇 Let’s talk about it in the comments after the transcript below.
🔵 Transcript
[00:00] April Pride:
Hey, it's April Pride, your host here on the High Guide podcast. I'd like to take a moment to remind you that we do discuss [cannabis microdosing] and psychedelics, and this podcast is intended for audiences 21 and over. Also, I am not a medical expert. We do discuss interventions and protocols, and you should consult your medical professional before moving forward with anything that we may discuss here on the show. Before we begin, I'd like to thank our show sponsor, Of Like Minds. Check out oflikeminds.co, that's oflikeminds, M-I-N-D-S dot C-O, to learn more about Seattle's trusted source for psilocybin. Hey there, today we're going to talk about [cannabis microdosing], but this time we're going to talk specifically about cannabis. Small doses of this versatile plant can have subtle yet impactful effects on well-being and functionality, and we're going to look at those.
[01:09] Sherry Horn:
When you start taking a tincture, how do you know how many drops to take? Some people need [microdosing cannabis benefits], and so they only take a drop. And so you had to start low and slow with one drop for a week and then raise it to two or three until it took away your pain. And so people would talk about it. Everyone that had that condition would talk about it. And so there was a great support group. We even had a facilitators group so that if somebody was trying it for the first time and they were scared, a group of us would go over there and be there with them, not getting high or using any of our own medicine, but just being there with them.
[01:50] April Pride:
Welcome back to How to Do the Pot. I'm April Pride, and I do the pot. This is the audio newsletter from The High Guide, Every Woman's Cannabis Handbook. If you'd rather read it, visit DoThePot.com to subscribe to the email newsletter. And if you like How to Do the Pot, please share it with someone and rate and review us on Apple Podcasts. It helps more people find the show. you just heard from Sherry Horn the former mayor of Laguna Woods California and a cannabis advocate who helps seniors learn how to use cannabis often by taking small doses to help with aches pains and stress taking small doses throughout the day to regulate pain or your mood is [cannabis microdosing] or as we like to say here at how to do the pot flying low you're not in the clouds but you feel lighter light enough to float Doesn't that sound like the perfect state in which to write out COVID? [cannabis microdosing] can refer to low-dose THC or low-dose THC with equal or greater parts of CBD in the formulation. To help you decipher what low-dose actually means, today we're digging into ratios and percentages on cannabis labels. So think of reading labels on cannabis products like a nutrition label. Your dietary goals dictate the ingredient you zero in on carbs, sugar, saturated fat. You get it. And you also get that your dietary goals change with cannabis labels. Your weed goals are not always the same. So how you read the label is determined by the ingredients you need to get your desired outcome. And just like not every diet is a winner, not every weed product is either. So please be open to experimenting. And experimenting with your best low-dose option, a tincture, vape pen, gummies, might mean spending the day floating. Thanks to several micro doses of CBD sprinkled with THC, the day is smoother, brighter, and, well, less of the same. If you or someone you love deserves to float, don't F it up by dosing her with more than she needs. Consuming legal cannabis means a new retail buying experience for many women. Need some help buying THC products? As the youngest African American woman to own a dispensary in the U.S., Hope Wiseman's vision is proving foundational to how we will all shop for cannabis in the future. Hope has some tips for choosing the right product at the right dispensary.
[04:13] Hope Wiseman:
You should be prepared to share details about your most recent experience with [cannabis microdosing]. What brand did you use? What dose did you take? How did it make you feel? And did you enjoy that feeling or would you like a different feeling? What is your desired outcome? If you have a good idea of these things in advance of coming to the dispensary, it could make the experience more pleasurable.
[04:35] April Pride:
Hope also reminds us what to expect from the people helping you out when you buy the pot, but tender.
[04:42] Hope Wiseman:
They are experts in the brands that they carry. They're talking directly to patients and customers all day, every day. They understand all the frequently asked questions. When someone first comes to a dispensary, a lot of times people go to their bud tender and they're looking for medical advice. And these are retail sales associates, and they are not medical professionals. They are not allowed to give medical advice, but a lot of them are highly trained on the science of cannabis. So there is a level of expertise that you can expect.
[05:23] April Pride:
If you're looking for a gentle and transformative psilocybin experience, let's hook you up with an Of Like Minds microdose. If that concept is new or in case you need a refresher, [microdosing psilocybin] is the practice of taking an imperceptible or some might say sub-perceptible dose of a psychedelic substance to enhance creativity, focus, and mood. And it just so happens Of Like Minds makes two fantastic microdose offerings. First is Of Like Minds Microdose Capsules. These little gems contain 0.15 grams of psilocybin, carefully sourced from our trusted Seattle-based supplier. This group has been extracting psilocybin for over three decades, so you know you're in good hands. The strain we've chosen for these capsules is called Melmac, named after, fun fact, the planet from the beloved 80s sitcom ALF. The original propagator's goal was to transport you to another planet. Melmac is known for inducing a euphoric state, which makes it ideal if you're seeking relief from depression. And shout out to my Pacific Northwest people, microdosing is great for seasonal affective disorder. In each package, there are 20 microdose capsules. That's a 10-week supply if you take one capsule twice a week. You could be spending $6 a day to alter your consciousness for a few hours with a Starbucks or Or you could be taking a microdose and rewriting your neural pathways to become a better version of yourself for life for real. Our second microdose offering is psilocybin bitters. These are versatile and easy to mix into any drink that you like. I really love that bitters can help reduce drinking by offering an alternative way to alter consciousness. You can mix the bitters into any mocktail and they're great. This is the perfect companion for dry January. The two ounce bottle contains 30.2 gram servings, giving you 15 weeks of microdosing. If you're looking for a super low key introduction to tripping, the capsules and our bitters are the answer. Microdosing is also a great option if you have a sensitive stomach. We've strained out the pulp, the culprit behind the nausea, leaving you with a virtually zero chance of an upset stomach. We've got some more exciting news to share. If you live in Seattle and you want to join us beginning in October, we're inviting 100 people to join us while we work with a microdose coach over 10 weeks during the darkest days in the Pacific Northwest later this fall. Sign up for the High Guide newsletter to stay in the loop for when of Like Minds microdose protocols will be available and to read more about all of their offerings and to learn all the ways that we're all of Like Minds. For today's high five, what the ratios and percentages on cannabis labels mean. Number one, CBD colon THC. When reading labels printed with CBD colon THC ratios, the number to the left of the colon always refers to CBD and the number to the right always refers to THC. My cheat is that C comes before T and To learn more about CBD colon THC ratio formulated products, listen to the pharma episode of how to do the pot. Number two, one colon one equal parts CBD and THC. When consumed simultaneously, CBD naturally diminishes the effects of THC, the psychoactive effects. The intoxicating effect of a one-to-one formulation is most similar to a glass of champagne. Number three, 20 colon one or 20 times CBD to one part THC. The much higher ratio of CBD means that the intoxicating properties of THC will be barely felt like after consuming a light beer, a pilsner. Number four, one colon three. Although most dual formulated products contain higher levels of CBD, you need to look out for the opposite, a higher number after the colon. This is tricky and will result in three times the THC you are expecting with the minimal amount of CBD to level off any anxiety that might induce. It is a common mistake to mix up the ratio. So just remember, again, the first number CBD, that's not going to get you high. Second number is THC, that's going to get you high. If that second number is bigger, you're going to be higher. Number five, 16%. Plus THC. Flower and pre-rolls products with THC levels around 16 to 21% and less than 1 to 2% CBD will induce very noticeable intoxicating effects. Extraction-based goods like oil cartridges have much higher levels of THC listed on their labels because these are concentrated products. A little goes a long way. Over 22% THC is a mental commitment at a minimum. Okay. with the potential to induce serious anxiety. Sometimes it is fun to see if you are up for the challenge, but you need to know what you're doing if you are getting in bed with 22% THC. Today's Strains with Just Right Ratios It's a 20 to one CBD to THC strain. It's the first choice that I usually recommend to those who are newish to cannabis and you can find it in dispensaries most everywhere. Canatonic is a one-to-one strain and it's a quiet high that soothes your body and mind, prevents and reduces inflammation. So you get a little bit of a balanced high and it does help with pain, but you know, you're not flying. Harlequin. It's consistently yields a two to one ratio. So two parts of CBD to one part THC. And it's for people who don't want to be getting high. It's a great daytime strain so you can work without stress, like cleaning out your garage. [cannabis microdosing] is a super interesting topic. There are a lot of ways to [microdosing cannabis benefits] and reasons to do it. Reports from [cannabis microdosing] and [microdosing psilocybin] both include boosted mood, better focus, and enhanced creativity. But there are a few effects specific to each plant that may help you choose one over the other. [psilocybin microdose effects] has shown some promise in PTSD recovery and in neuroplasticity, which is the brain's ability to reorganize and form new connections. It also has apparently helped reduce the frequency and intensity of migraines and cluster headaches for some. If you have opposite the paranoia that sometimes comes with high doses of THC. People also [cannabis microdosing] to combat insomnia or simply improve sleep. If the word sleep caught your attention, we're going to devote the next episode of the show to this, cannabis and sleep. So keep your dial tuned. Thank you for listening to the High Guide podcast, and we'll see you next time. A quick final thanks to our show sponsor of Like Minds, Seattle's trusted source for psilocybin, We've got one more episode on psilocybin in women with Jennifer coming up, so stay tuned. And if you like this episode, be sure to check out the show notes where we've linked to our show sponsor of Like Minds event page to learn more about tickets for Jennifer's upcoming Q&A with me here in Seattle on November 15th. Space is limited, so RSVP, ASAP. Join us in our next episode, the final chapter of this three-part series. Thank you, as always, for listening to The High Guide, and we'll see you next time.
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